About anemia of kidney disease, how much do you know

1. Erythropoietin (EPO) deficiency, EPO about 90% by renal tubular synthesis, uremic patients due to renal fibrosis, EPO synthesis significantly reduced, the vast majority of patients with EPO deficiency.

2.Iron and vitamin deficiency dialysis patients due to loss of appetite and other reasons, resulting in decreased iron intake, iron content decreased significantly, the patient has a significant inflammatory state, increased oxidative stress, resulting in increased iron use of iron deficiency In addition, a large number of Vitamin loss in dialysis, lack of supplement, may also cause the lack of hematopoietic raw materials.

3. secondary hyperparathyroidism, dialysis patients with calcium and phosphorus metabolism, secondary hyperparathyroidism, hypercapnia iPTH on the formation of red blood cells inhibit the role. The rise of iPTH causes bone metabolism disorders, changes in bone marrow hematopoietic microenvironment, hematopoietic stem cell activation is inhibited, erythropoiesis is reduced.

4. Dialysis deficiency, blood loss, autoimmune diseases and other reasons will increase anemia. Anemia symptoms Clinical manifestations: mild anemia usually no obvious symptoms. When anemia intensifies, often manifested as fatigue,

difficulty breathing, other symptoms include difficulty concentrating, dizziness, sleep disorders, chills and headaches. The above symptoms are slow, the body can compensate. Severe anemia, cardiac output was significantly increased, there may be palpitations, physical decline and left ventricular hypertrophy. Some patients with hemostatic function, immune function, sexual function and cognitive decline at the same time.