11 strokes to kidney failure is no longer exacerbated

Several measures to slow the progress of CRF:

(1) Elimination of CRF deterioration risk factors (as described above).

(2) adhere to the cause of CRF treatment: such as chronic nephritis, lupus nephritis, purpura nephritis, IgA nephropathy, diabetic nephropathy, etc., need to adhere to long-term treatment.

(3) Diet therapy: the application of low-protein, low-phosphorus diet, alone or with EAA / KA, to use α-KA more favorable. The method may have the effect of reducing renal hypercalcemia and renal tubular metabolism. It has been reported that the use of low-protein diets plus essential amino acids or alpha-keto acids in the treatment of patients with chronic renal failure before dialysis can slow down the decline in serum creatinine (Scr-1), but with the exception of malnutrition, muscle loss (GFR) in these patients was determined by nuclear medicine method. It was found that the rate of GFR decline in CRF patients was slowed down after treatment with the above diet therapy.

(4) to reduce the glomerular hyperfiltration: ① timely control of hypertension, to delay the development of chronic renal failure is of great significance, foreign literature has been a lot of research reports. Bergstrom and other reports, timely, active and reasonable control of blood pressure and follow-up follow-up, is to delay the progress of CRF main factors, some other authors have repeatedly reported that control of blood pressure to delay the progress of CRF has its importance can not be ignored. ② Invertase inhibitor (ACEI): such as Captopril (6.25 ~ 25mg, 3 times / day) orally, diabetic nephropathy and other high filtration effect, and can slow down the Scr rate. The results of a multicenter clinical study in 30 hospitals in North America showed that the rate of Scr descending in the treatment group was 24 months (22 to 58 months) compared with the control group in 409 patients with diabetic nephropathy treated with Captopril (25 mg, 3 times / day) Slow, enter the end stage or death than the control group of patients reduced by 50.5%; also reported that non-diabetic nephropathy CRF patients with Captopril can also make CRF patients Scr slow down.

(5) to reduce the small tube  interstitial calcium phosphorus deposition: such as low-phosphorus diet, α-KA, phosphorus binding agent. Other measures are still in the exploration, such as some active vitamin D3 and so on.

(6) to reduce renal tubular metabolism: such as alkaline drugs, low-protein diet, rhubarb preparations, Cordyceps preparations, etc., there are experimental results suggest that this effect, still need more clinical observations to confirm.

(7) to correct hyperlipidemia: the application of unsaturated fatty acids, lipid-lowering drugs, may have slowed the role of glomerular sclerosis.

(8) to reduce uremic toxins accumulation: such as low-protein diet, adsorption therapy, intestinal dialysis and so on.

(9) Ca2 + antagonist: may have slowed the role of glomerular sclerosis, the mechanism may be related to control of hypertension, reduce glomerular hyperfiltration, and reduce renal calcium and phosphorus deposition.

(10) antiplatelet drugs: may have to reduce renal microcirculation thrombosis, slow down the role of glomerular sclerosis, need further study.

(11) other drugs: blood circulation drugs, antioxidants, etc., may also have to slow down the role of glomerular sclerosis or renal interstitial fibrosis, pending further study.

Early treatment of chronic renal failure, to delay the development of the disease, improve the prognosis of patients, is of great significance; middle and late patients with chronic renal failure, diet and drug therapy can also ease the symptoms, dialysis time is delayed. In the application of non-dialysis treatment, the need for nutrition therapy based on, and with the application of drugs to delay the progress of CRF, azotemia patients, should be added with intestinal cathartic or oral absorption therapy. In short, should strengthen the comprehensive treatment, from all aspects to reduce the symptoms of CRF, improve patient quality of life, delay the development of CRF.