Treatment of nephropathy The advent of new drugs, nearly half of patients with nephritis treatment will be changed!

Yesterday pushed the 7 types of IgA nephropathy, some patients said they did not have kidney, so a list of protein creatinine values ​​asked me whether it is IgA nephropathy?

With urinary protein and creatinine is not seen pathological type, if you have the following three cases, IgA nephropathy should be suspected:

1, upper respiratory tract infection or tonsillitis attack occurs at the same time or short-term gross hematuria, infection control, gross hematuria disappeared or reduced;

2, the typical deformity of red blood cell urine (spore or spine), with or without proteinuria;

3, serum IgA increased.

Treatment of nephropathy The advent of new drugs, nearly half of patients with nephritis treatment will be changed!

Deformity of red blood cells

In addition, half of patients with IgA nephropathy have hypertension.

IgA nephropathy embarrassment: dilemma

Difficulty: We know that patients with IgA nephropathy below 1g urinary protein usually do not use hormones (nor do they necessarily work), whereas propranolol and losartan have a limited role of reducing protein, resulting in a long history of IgA nephropathy No specific drugs, reduce protein weakness.

Since there is no effective way to further reduce the protein, then I take a step back to maintain a small amount of urine protein does not?

Reluctantly: This is a more worrying place: urinary protein IgA nephropathy, not down.

why? Because it does not like small lesions of kidney disease, membranous nephropathy that a small amount of protein does not matter. Small lesions, membranous patients, if the protein has been less, zero grams, twenty years later is still a good man. However, IgA nephropathy does not work, and even a small amount of urine protein is a hazard to the kidneys and increases the risk of kidney failure.

How to do? Do not worry, we come to the focus of this article:

New drug for IgA nephropathy: TRF-budesonide

Treatment of nephropathy The advent of new drugs, nearly half of patients with nephritis treatment will be changed!


The researchers selected 150 patients with IgA nephropathy and persistent proteinuria from 62 kidney hospitals in ten European countries. By 1: 1: 1 ratio were randomly divided into 3 groups:

Budesonide 16mg / day

Budesonide 8mg / day

3. Placebo

Once daily, 1 hour before breakfast. At the same time to all patients Pulley, sartan drug treatment.

Monitoring indicators: urinary protein creatinine ratio (normal glomerular filtration rate, instead of 24-hour urine protein quantitative).

Treatment of nephropathy The advent of new drugs, nearly half of patients with nephritis treatment will be changed!

result:

After 9 months of treatment

1. Budesonide 16mg / day group, urinary creatinine decreased by an average of 27.3%;

Budesonide 8mg / day group, urinary protein creatinine decreased by an average of 21.5%;

The urinary creatinine ratio increased 2.7% in the placebo group.

The results show that budesonide can effectively reduce urinary protein in patients with IgA nephropathy.

If you want to learn more about kidney disease, please click here, Beijing kidney hospital for you