How to distinguish acute chronic glomerulonephritis

The difference between acute chronic glomerulonephritis! Most patients with chronic nephritis etiology, clinical features for the long course of disease, there can be a period of asymptomatic period, was slow progressive course of disease.

Acute glomerulonephritis

Clinically manifested as acute onset, hematuria, proteinuria, edema, hypertension and glomerular filtration rate decreased characteristics of glomerular disease, it is also often referred to as acute nephritis syndrome. The vast majority of clinically acute streptococcal glomerulonephritis after infection.

Chronic glomerulonephritis

Referred to as chronic nephritis, refers to proteinuria, hematuria, hypertension, edema as the basic clinical manifestations, different ways of onset, disease progression, slow progress of the disease can be different degrees of renal dysfunction, and ultimately the development of chronic renal failure A group of glomerulopathy. As the disease type of this group and the disease is different, the main clinical manifestations are different, the disease was diversified.

Acute and chronic glomerulonephritis What is the difference?

Urine routine examination has varying degrees of proteinuria, sediment microscopy can be seen red blood cells, the majority of patients have varying degrees of hypertension and renal dysfunction. Chronic nephritis clinical manifestations are similar, but the pathological type and severity of lesions vary. According to the majority of glomerular major lesions, divided into mesangial proliferative glomerulonephritis, membranous nephropathy, focal segmental glomerulosclerosis, mesangial capillary glomerulonephritis, hyperplastic sclerosing glomerulonephritis.

Acute streptococcal infection after nephritis delayed healing, the course of more than 1 year can be transferred to chronic nephritis. However, most of the chronic nephritis is not extended by acute nephritis, generally due to long-term immune mechanism and long-term changes in renal hemodynamics, renal vascular changes, mesangial function caused by changes.


Previously considered that acute glomerulonephritis if proteinuria and microscopic hematuria for 6 months to 1 year or more that has been transferred to chronic, renal biopsy and clinical data in recent years found that acute renal inflammation after renal abnormalities and renal biopsy activity In 2 to 3 years follow-up gradually disappear. So should not only time to judge the distinction between acute or chronic glomerulonephritis.

According to follow-up data found that the clinical manifestations of acute glomerulonephritis disappeared in the kidney can still have residual lesions, but sometimes glomerular fibrosis, and sometimes patients with urinary routine examination is still found in protein and red blood cells, and biopsy found that the kidney In the diffuse inflammatory lesions have disappeared, only the residual lesions, the so-called "defective healing." Some patients with the follow-up time, biopsy found in the glomerular fibrosis increased trend. In case of the above situation should continue to follow-up observation, pay attention to the possibility of development of chronic glomerulonephritis.

Patients with chronic nephritis also have an acute onset tendency, and every time the disease is relatively stable, the patient is in a short period of time (3 to 5 days or even 1 to 2 days) due to a sudden increase in the condition of the respiratory tract infection or other sudden malignancy A large number of proteinuria, and even gross hematuria, tube type increased. Significant edema and high blood pressure, and deterioration of renal function. By appropriate treatment, the condition can be alleviated, basically restored to the original level, may also lead to disease progression, into the uremic period.

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